This article describes the experimental set-up and pharmacokinetic modeling of P-glycoprotein function in the rat blood-brain barrier using [ 11 C]verapamil as the substrate and cyclosporin A as an inhibitor of P-gp. [ 11 C]verapamil was administered to rats as an i.v. bolus dose followed by graded
The functional role of P-Glycoprotein in the blood–Brain barrier
✍ Scribed by Judith van Asperen; Ulrich Mayer; Olaf van Tellingen; Jos H. Beijnen
- Book ID
- 109388844
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 122 KB
- Volume
- 86
- Category
- Article
- ISSN
- 0022-3549
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