✦ LIBER ✦

Decreased blood–brain barrier P-glycoprotein function in the progression of Parkinson’s disease, PSP and MSA

✍ Scribed by A. L. Bartels; A. T. M. Willemsen; R. Kortekaas; B. M. de Jong; R. de Vries; O. de Klerk; J. C. H. van Oostrom; A. Portman; K. L. Leenders

Publisher: Springer
Year: 2008
Tongue: English
Weight: 371 KB
Volume: 115
Category: Article
ISSN: 1435-1463
DOI: 10.1007/s00702-008-0030-y

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Pharmacokinetics of P-glycoprotein inhib

Pharmacokinetics of P-glycoprotein inhibition in the rat blood-brain barrier

✍ Stina Syvänen; Andrew Hooker; Obaidur Rahman; Helena Wilking; Gunnar Blomquist; 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 338 KB

This article describes the experimental set-up and pharmacokinetic modeling of P-glycoprotein function in the rat blood-brain barrier using [ 11 C]verapamil as the substrate and cyclosporin A as an inhibitor of P-gp. [ 11 C]verapamil was administered to rats as an i.v. bolus dose followed by graded

Enhanced cerebral uptake of receptor lig

Enhanced cerebral uptake of receptor ligands by modulation of P-glycoprotein function in the blood–brain barrier

✍ P. Doze; A. Van Waarde; P.H. Elsinga; N.H. Hendrikse;; W. Vaalburg 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 170 KB 👁 2 views

Low cerebral uptake of some therapeutic drugs can be enhanced by modulation of P-glycoprotein (P-gp), an ATP-driven drug efflux pump at the blood-brain barrier (BBB). We investigated the possibility of increasing cerebral uptake of the beta-adrenergic ligands S-1'-[(18)F]-fluorocarazolol (FCAR) and

Brain penetration of methadone (R)- and

Brain penetration of methadone (R)- and (S)-enantiomers is greatly increased by P-glycoprotein deficiency in the blood–brain barrier of Abcb1a gene knockout mice

✍ Jun-Sheng Wang; Ying Ruan; RobinM. Taylor; JenniferL. Donovan; JohnS. Markowitz; 📂 Article 📅 2004 🏛 Springer 🌐 English ⚖ 184 KB

Development of a P-glycoprotein knockout

Development of a P-glycoprotein knockout model in rodents to define species differences in its functional effect at the blood–brain barrier

✍ Leanne Cutler; Colin Howes; Nigel J. Deeks; Tania L. Buck; Phil Jeffrey 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 219 KB

The objective of this study was to establish the optimal blood concentrations of the potent P-glycoprotein (P-gp) inhibitor GF120918 (Elacridar) required to achieve maximal knockout of this efflux transporter in the blood-brain barrier (BBB) of mice, rats, and guinea pigs. Genetic mdr1a/b(-/-) knock