𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Functional Evidence for P-glycoprotein at the Nose-Brain Barrier

✍ Scribed by Candace L. Graff; Gary M. Pollack


Book ID
106492505
Publisher
Springer US
Year
2005
Tongue
English
Weight
158 KB
Volume
22
Category
Article
ISSN
0724-8741

No coin nor oath required. For personal study only.


πŸ“œ SIMILAR VOLUMES


Development of a P-glycoprotein knockout
✍ Leanne Cutler; Colin Howes; Nigel J. Deeks; Tania L. Buck; Phil Jeffrey πŸ“‚ Article πŸ“… 2006 πŸ› John Wiley and Sons 🌐 English βš– 219 KB

The objective of this study was to establish the optimal blood concentrations of the potent P-glycoprotein (P-gp) inhibitor GF120918 (Elacridar) required to achieve maximal knockout of this efflux transporter in the blood-brain barrier (BBB) of mice, rats, and guinea pigs. Genetic mdr1a/b(-/-) knock

Enhanced cerebral uptake of receptor lig
✍ P. Doze; A. Van Waarde; P.H. Elsinga; N.H. Hendrikse;; W. Vaalburg πŸ“‚ Article πŸ“… 2000 πŸ› John Wiley and Sons 🌐 English βš– 170 KB πŸ‘ 2 views

Low cerebral uptake of some therapeutic drugs can be enhanced by modulation of P-glycoprotein (P-gp), an ATP-driven drug efflux pump at the blood-brain barrier (BBB). We investigated the possibility of increasing cerebral uptake of the beta-adrenergic ligands S-1'-[(18)F]-fluorocarazolol (FCAR) and