Functional Evidence for P-glycoprotein at the Nose-Brain Barrier
β Scribed by Candace L. Graff; Gary M. Pollack
- Book ID
- 106492505
- Publisher
- Springer US
- Year
- 2005
- Tongue
- English
- Weight
- 158 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0724-8741
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The objective of this study was to establish the optimal blood concentrations of the potent P-glycoprotein (P-gp) inhibitor GF120918 (Elacridar) required to achieve maximal knockout of this efflux transporter in the blood-brain barrier (BBB) of mice, rats, and guinea pigs. Genetic mdr1a/b(-/-) knock
Low cerebral uptake of some therapeutic drugs can be enhanced by modulation of P-glycoprotein (P-gp), an ATP-driven drug efflux pump at the blood-brain barrier (BBB). We investigated the possibility of increasing cerebral uptake of the beta-adrenergic ligands S-1'-[(18)F]-fluorocarazolol (FCAR) and