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Up-regulation of P-glycoprotein expression by glutathione depletion-induced oxidative stress in rat brain microvessel endothelial cells

✍ Scribed by Hao Hong; Ying Lu; Zhao-Ning Ji; Guo-Qing Liu

Book ID
111179689
Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
622 KB
Volume
98
Category
Article
ISSN
0022-3042

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## Abstract A major concern regarding the chronic administration of antiretroviral drugs is the potential for induction of drug efflux transporter expression (i.e., P‐glycoprotein, P‐gp) at tissue sites that can significantly affect drug distribution and treatment efficacy. Previous data have shown