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Glutathione Conjugation of Bay- and Fjord-Region Diol Epoxides of Polycyclic Aromatic Hydrocarbons by Glutathione Transferases M1-1 and P1-1

✍ Scribed by Sundberg, Kathrin; Widersten, Mikael; Seidel, Albrecht; Mannervik, Bengt; Jernström, Bengt


Book ID
120590248
Publisher
American Chemical Society
Year
1997
Tongue
English
Weight
262 KB
Volume
10
Category
Article
ISSN
0893-228X

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## Abstract Carcinogenic polycyclic aromatic hydrocarbons(a) form DNA adducts via a complex metabolic activation pathway that includes cytochrome P450(a) 1A1, whereas intermediate metabolites can be detoxified by conjugation through pathways including glutathione s‐transferase M1 (GSTM1). PAH‐DNA a