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Detoxication of carcinogenic fjord-region diol epoxides of polycyclic aromatic hydrocarbons by glutathione transferase P1-1 variants and glutathione

✍ Scribed by Kathrin Sundberg; Albrecht Seidel; Bengt Mannervik; Bengt Jernström


Book ID
117109923
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
101 KB
Volume
438
Category
Article
ISSN
0014-5793

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## Abstract Carcinogenic polycyclic aromatic hydrocarbons(a) form DNA adducts via a complex metabolic activation pathway that includes cytochrome P450(a) 1A1, whereas intermediate metabolites can be detoxified by conjugation through pathways including glutathione s‐transferase M1 (GSTM1). PAH‐DNA a