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Activity of Four Allelic Forms of Glutathione S-Transferase hGSTP1-1 for Diol Epoxides of Polycyclic Aromatic Hydrocarbons

✍ Scribed by Xun Hu; Hong Xia; Sanjay K. Srivastava; Christian Herzog; Yogesh C. Awasthi; Xinhua Ji; Piotr Zimniak; Shivendra V. Singh


Book ID
115580877
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
135 KB
Volume
238
Category
Article
ISSN
0006-291X

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## Abstract Carcinogenic polycyclic aromatic hydrocarbons(a) form DNA adducts via a complex metabolic activation pathway that includes cytochrome P450(a) 1A1, whereas intermediate metabolites can be detoxified by conjugation through pathways including glutathione s‐transferase M1 (GSTM1). PAH‐DNA a