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Differences in the catalytic efficiencies of allelic variants of glutathione transferase P1-1 towards carcinogenic diol epoxides of polycyclic aromatic hydrocarbons

✍ Scribed by Sundberg, K


Book ID
125547482
Publisher
Oxford University Press
Year
1998
Tongue
English
Weight
91 KB
Volume
19
Category
Article
ISSN
0143-3334

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## Abstract Carcinogenic polycyclic aromatic hydrocarbons(a) form DNA adducts via a complex metabolic activation pathway that includes cytochrome P450(a) 1A1, whereas intermediate metabolites can be detoxified by conjugation through pathways including glutathione s‐transferase M1 (GSTM1). PAH‐DNA a