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Glial Cell Line-Derived Neurotrophic Factor (GDNF) Gene Delivery Protects Dopaminergic Terminals from Degeneration

✍ Scribed by Bronwen Connor; Dorothy A. Kozlowski; James R. Unnerstall; John D. Elsworth; Jennifer L. Tillerson; Timothy Schallert; Martha C. Bohn

Book ID: 115607488
Publisher: Elsevier Science
Year: 2001
Tongue: English
Weight: 199 KB
Volume: 169
Category: Article
ISSN: 0014-4886
DOI: 10.1006/exnr.2001.7638

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## Abstract Glial cell line‐derived neurotrophic factor (GDNF) promotes the survival and functions of neurons. It has been shown to be a promising candidate in the treatment of ischemia and other neurodegenerative diseases. We transfected mouse astrocytes in primary cultures with a human GDNF gene