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Glial cell line-derived neurotrophic factor protects astrocytes from staurosporine- and ischemia- induced apoptosis

✍ Scribed by Albert Cheung Hoi Yu; Rong Yu Liu; Yun Zhang; Hao Rui Sun; Lu Ye Qin; Lok Ting Lau; Bing Yi Wu; Hung Kit Hui; Man Yeung Heung; Ji Sheng Han

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
899 KB
Volume
85
Category
Article
ISSN
0360-4012

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✦ Synopsis

Abstract

Glial cell line‐derived neurotrophic factor (GDNF) promotes the survival and functions of neurons. It has been shown to be a promising candidate in the treatment of ischemia and other neurodegenerative diseases. We transfected mouse astrocytes in primary cultures with a human GDNF gene and found that their conditioned medium could not only support the growth and survival of cultured dopaminergic neurons but also protect astrocytes from staurosporine‐ and ischemia‐induced apoptosis. This indicated that these transfected astrocytes could release GDNF. A similar protective effect on astrocytes against apoptosis was evident when recombinant human GDNF was used. Moreover, GDNF reduced caspase‐3 activity but not that of caspase‐1 in cultured astrocytes after ischemia treatment. Thus, GDNF protects astrocytes from apoptosis by inhibiting the activation of caspase‐3. © 2007 Wiley‐Liss, Inc.

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