Human SK-N-AS neuroblastoma and U-87MG glioblastoma cell lines were found to secrete relatively high levels of glial cell line-derived neurotrophic factor (GDNF). In response to growth factors, cytokines, and pharmacophores, the two cell lines differentially regulated GDNF release. A 24-hr exposure
Dopamine increases glial cell line-derived neurotrophic factor in human fetal astrocytes
β Scribed by Noa Kinor; Revital Geffen; Eliahu Golomb; Tova Zinman; Gal Yadid
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 175 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0894-1491
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Glial cell line-derived neurotrophic factor (GDNF) is a neurotrophic factor that influences the survival and function of several neuronal populations in the central (CNS) and peripheral nervous systems. The actions of GDNF are mediated by a multicomponent receptor complex composed of the tyrosine ki
Glial cell line-derived neurotrophic factor (GDNF) promotes survival of mesencephalic dopaminergic neurons in vitro and when injected locally into the brains of lesioned adult animals. Here, we show that GDNF (3 Β΅g per day and higher) can promote the survival of all (retrogradely labeled) axotomized