Human SK-N-AS neuroblastoma and U-87MG glioblastoma cell lines were found to secrete relatively high levels of glial cell line-derived neurotrophic factor (GDNF). In response to growth factors, cytokines, and pharmacophores, the two cell lines differentially regulated GDNF release. A 24-hr exposure
Regulation of tyrosine hyroxylase gene transcription in ventral midbrain by glial cell line-derived neurotrophic factor
β Scribed by Chad J. Messer; Jin H. Son; Tong H. Joh; Klaus D. Beck; Eric J. Nestler
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 254 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0887-4476
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Glial cell line-derived neurotrophic factor (GDNF) has been shown to protect cranial and spinal motoneurons, that suggests potential uses of GDNF in the treatment of spinal cord injury and motor neuron diseases. We examined neuroprotective effect of human GDNF encoded by an adenovirus vector (AxCAhG
Glial cell line-derived neurotrophic factor (GDNF) promotes survival of mesencephalic dopaminergic neurons in vitro and when injected locally into the brains of lesioned adult animals. Here, we show that GDNF (3 Β΅g per day and higher) can promote the survival of all (retrogradely labeled) axotomized