Glial cell line-derived neurotrophic factor (GDNF) gene and schizophrenia: polymorphism screening and association analysis
β Scribed by Kyu-Bak Lee; Hiroshi Kunugi; Shinichiro Nanko
- Book ID
- 117333908
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 77 KB
- Volume
- 104
- Category
- Article
- ISSN
- 0165-1781
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Glial cell line-derived neurotrophic factor (GDNF) was first discovered as a potent survival factor for midbrain dopaminergic neurons and was then shown to rescue these neurons in animal models of Parkinson's disease. GDNF is a more potent survival factor for dopaminergic neurons and the noradrenerg
Human SK-N-AS neuroblastoma and U-87MG glioblastoma cell lines were found to secrete relatively high levels of glial cell line-derived neurotrophic factor (GDNF). In response to growth factors, cytokines, and pharmacophores, the two cell lines differentially regulated GDNF release. A 24-hr exposure