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Germline Mutations in Cancer Susceptibility Genes: An Overview for Nurses

✍ Scribed by Deborah J. MacDonald


Book ID
116888250
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
153 KB
Volume
27
Category
Article
ISSN
0749-2081

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## Abstract Lynch syndrome is defined by the presence of germline mutations in mismatch repair (MMR) genes. Several models have been recently devised that predict mutation carrier status (Myriad Genetics, Wijnen, Barnetson, PREMM and MMRpro models). Families at moderate‐high risk for harboring a Ly