Germ line BRCA1 & BRCA2 mutations in Greek breast/ovarian cancer families: 5382insC is the most frequent mutation observed
โ Scribed by A. Ladopoulou; C. Kroupis; I. Konstantopoulou; L. Ioannidou-Mouzaka; A.C. Schofield; A. Pantazidis; S. Armaou; I. Tsiagas; E. Lianidou; E. Efstathiou; C. Tsionou; C. Panopoulos; M. Mihalatos; G. Nasioulas; D. Skarlos; N.E. Haites; G. Fountzilas; N. Pandis; D. Yannoukakos
- Book ID
- 117467239
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 311 KB
- Volume
- 185
- Category
- Article
- ISSN
- 0304-3835
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## Communicated by Mark H. Paalman Germline mutations in breast cancer susceptibility genes, BRCA1 and BRCA2, are responsible for a substantial proportion of high-risk breast and breast/ovarian cancer families. To characterize the spectrum of BRCA1 and BRCA2 mutations, we screened Czech families w
Germline mutations in BRCA1 and BRCA2 account for majority of hereditary breast and ovarian cancer. The complete coding sequence analysis of both genes was carried out in 197 breast/ovarian cancer patients from high-risk families and 53 patients with sporadic breast/ovarian cancer. In summary, 59 mu