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Large regional differences in the frequency of distinct BRCA1/BRCA2 mutations in 517 Dutch breast and/or ovarian cancer families

โœ Scribed by L.C. Verhoog; A.M.W. van den Ouweland; E. Berns; M.M. van Veghel-Plandsoen; I.L. van Staveren; A. Wagner; C.C.M. Bartels; M.M.A. Tilanus-Linthorst; P. Devilee; C. Seynaeve; D.J.J. Halley; M.F. Niermeijer; J.G.M. Klijn; H. Meijers-Heijboer


Book ID
117987476
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
218 KB
Volume
37
Category
Article
ISSN
0959-8049

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Germline mutations of BRCA1 and BRCA2 in
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Germline mutations in the BRCA1 and BRCA2 genes are responsible for the predisposition and development of familial breast and/or ovarian cancer. Most mutations of BRCA1 and BRCA2 associated with breast and/or ovarian cancer result in truncated proteins. To investigate the presence of BRCA1 and BRCA2