Genomic rearrangements of theAPCtumor-suppressor gene in familial adenomatous polyposis
β Scribed by L.-K. Su; G. Steinbach; J.C. Sawyer; M. Hindi; P.A. Ward; P.M. Lynch
- Book ID
- 106137452
- Publisher
- Springer
- Year
- 2000
- Tongue
- English
- Weight
- 320 KB
- Volume
- 106
- Category
- Article
- ISSN
- 0340-6717
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π SIMILAR VOLUMES
Patients with Familial Adenomatous Polyposis (FAP) manifest numerous colorectal adenomas as well as benign and malignant extra-colonic lesions. Adenomatous polyposis coli (APC) gene mutations are the underlying genetic defect in FAP. We analyzed germline D N A of 81 unrelated FAP patients and evalua
## Development of one hundred or more adenomas in the colon and rectum is diagnostic for the dominantly inherited, autosomal disease Familial Adenomatous Polyposis (FAP). It is possible to identify a mutation in the Adenomatous Polyposis Coli (APC) gene in approximately 80% of the patients, and alm