First large rearrangement in the MUTYH gene and attenuated familial adenomatous polyposis syndrome
β Scribed by E Rouleau; H Zattara; C Lefol; T Noguchi; A Briaux; B Buecher; V Bourdon; H Sobol; R Lidereau; S Olschwang
- Book ID
- 110889272
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 657 KB
- Volume
- 80
- Category
- Article
- ISSN
- 0009-9163
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π SIMILAR VOLUMES
## Development of one hundred or more adenomas in the colon and rectum is diagnostic for the dominantly inherited, autosomal disease Familial Adenomatous Polyposis (FAP). It is possible to identify a mutation in the Adenomatous Polyposis Coli (APC) gene in approximately 80% of the patients, and alm
## Germline mutations within the adenomatous polyposis coli (APC ) gene, a tumor suppressor gene, are responsible for most cases of familial adenomatous polyposis (FAP), an autosomal dominantly inherited predisposition to colorectal cancer. To date, more than 300 germ-line causative mutations with