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Germline mutations in APC and MUTYH are responsible for the majority of families with attenuated familial adenomatous polyposis

✍ Scribed by M Nielsen; FJ Hes; FM Nagengast; MM Weiss; EM Mathus-Vliegen; H Morreau; MH Breuning; JT Wijnen; CMJ Tops; HFA Vasen

Book ID
110888362
Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
122 KB
Volume
71
Category
Article
ISSN
0009-9163

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Germline hypermethylation of the APC pro
Germline hypermethylation of the APC promoter is not a frequent cause of familial adenomatous polyposis in APC/MUTYH mutation negative families
✍ Jordi Romero-GimΓ©nez; Higinio Dopeso; Ignacio Blanco; Angel Guerra-Moreno; Sara πŸ“‚ Article πŸ“… 2007 πŸ› John Wiley and Sons 🌐 French βš– 226 KB πŸ‘ 2 views

## Abstract Familial adenomatous polyposis (FAP) is an autosomal dominant syndrome predisposing to colorectal cancer and affects 1 in 5–10,000 births. Inheritance of a mutant allele of the adenomatous polyposis coli (__APC__) gene is the cause of ∼80% of FAP and 20–30% of an attenuated form of FAP