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Detection of five novel germline mutations of the APC gene in Irish familial adenomatous polyposis families

✍ Scribed by Maureen J. O'Sullivan; Tanya M. Mulcahy; J. Cambell; Christoir B. O'Suilleabhain; William O. Kirwan; Cuimin T. Doyle; Tommie V. McCarthy


Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
420 KB
Volume
11
Category
Article
ISSN
1059-7794

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Inactivation of the adenomatous polyposis coli (APC) gene has been shown to initiate the majority of colorectal cancer (CRC), including a familial form called familial adenomatous polyposis (FAP). One consequence of the APC mutation is the activation of the ␀-catenin (CTNNB1)/T-cell transcription fa