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Topoisomerase-I- and Alu-mediated genomic deletions of theAPCgene in familial adenomatous polyposis

✍ Scribed by Cao, Xia; Eu, Kong; Seow-Choen, Francis; Zhao, Yi; Cheah, Peh

Book ID
113043683
Publisher
Springer
Year
2001
Tongue
English
Weight
90 KB
Volume
108
Category
Article
ISSN
0340-6717

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## Germline mutations within the adenomatous polyposis coli (APC ) gene, a tumor suppressor gene, are responsible for most cases of familial adenomatous polyposis (FAP), an autosomal dominantly inherited predisposition to colorectal cancer. To date, more than 300 germ-line causative mutations with