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Genomic imprinting in an Angelman and Prader-Willi translocation family

✍ Scribed by Hultén, M.; Armstrong, S.; Challinor, P.; Gould, C.; Hardy, G.; Leedham, P.; Lee, T.; Mckeown, C.

Book ID: 122847980
Publisher: The Lancet
Year: 1991
Tongue: English
Weight: 297 KB
Volume: 338
Category: Article
ISSN: 0140-6736
DOI: 10.1016/0140-6736(91)90652-6

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## Abstract Genomic imprinting is an epigenetic mechanism resulting in the preferential expression of the maternal or paternal alleles of a specific subset of genes in the mammalian genome. A key but relatively unexplored question is how imprints are established in the germline. New observations^(1