Imprinting mechanisms and genes involved in Prader-Willi and Angelman syndromes
β Scribed by Robert D. Nicholls
- Book ID
- 115647673
- Publisher
- Elsevier Science
- Year
- 1994
- Weight
- 702 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1044-5781
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Prader-Willi syndrome (PWS) and Angelman syndrome (AS) are clinically distinct complex disorders mapped to chromosome 15q11-q13. They both have characteristic neurologic, developmental, and behavioral phenotypes plus other structural and functional abnormalities. However, the cognitive and neurologi
## Abstract Genomic imprinting is an epigenetic mechanism resulting in the preferential expression of the maternal or paternal alleles of a specific subset of genes in the mammalian genome. A key but relatively unexplored question is how imprints are established in the germline. New observations^(1