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Genomic imprinting and candidate genes in the Prader—Willi and Angelman syndromes

✍ Scribed by Nicholls, Robert D.

Book ID: 123227117
Publisher: Elsevier Science
Year: 1993
Tongue: English
Weight: 31 KB
Volume: 3
Category: Article
ISSN: 0959-437X
DOI: 10.1016/S0959-437X(05)80101-7

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Prader-Willi syndrome (PWS) and Angelman syndrome (AS) are clinically distinct complex disorders mapped to chromosome 15q11-q13. They both have characteristic neurologic, developmental, and behavioral phenotypes plus other structural and functional abnormalities. However, the cognitive and neurologi