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Genetics of bipolar affective disorder

✍ Scribed by John I. Nurnberger; Tatiana Foroud

Publisher
Springer
Year
2000
Tongue
English
Weight
632 KB
Volume
2
Category
Article
ISSN
1523-3812

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## As part of a four-center NIMH Genetics Initiative on Bipolar Disorder, a genome screen using 365 markers was performed on 540 DNAs from 97 families, enriched for affected relative pairs. This is the largest uniformly ascertained and assessed linkage sample for this disease, and includes 232 subj

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We have used genetic linkage analysis in an effort to identify a gene responsible for bipolar affective disorder (BAD) in an Old Order Amish pedigree. The initial study of this pedigree showed strong evidence for linkage of the chromosome 11p15 markers HRAS1 and the insulin gene (INS) to BAD, wherea