~ W e have tested the hypothesis that DNA markers in the MAOA gene show allelic association with bipolar affective disorder. Eighty-four unrelated Caucasian patients with DSM 111-R bipolar disorder and 84 Caucasian controls were typed for three markers in MAOA a dinucleotide repeat in intron 2, a VN
Evidence for a genetic association between alleles of monoamine oxidase a gene and bipolar affective disorder
β Scribed by Lim, Lionel C. C. ;Powell, John ;Sham, Pak ;Castle, David ;Hunt, Neil ;Murray, Robin ;Gill, Michael
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- English
- Weight
- 757 KB
- Volume
- 60
- Category
- Article
- ISSN
- 0148-7299
No coin nor oath required. For personal study only.
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Monoamine oxidases catalyse the oxidative degradation of biogenic amines including neurotransmitters such as noradrenaline, dopamine, and 5-hydroxytryptamine (5-HT). Three groups have reported positive associations of the monoamine oxidase A (MAOA) gene with bipolar affective disorder although other
## Abstract Monoamine oxidase A (MAOA) has been implicated in the control of aggression and/or impulsivity in humans and been involved in suicide. This gene has a functional polymorphism in which there is a variable number tandem repeat (VNTR) in the upstream region (MAOAβuVNTR). We hypothesized th