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No evidence of association between dopamine D3 receptor gene and bipolar affective disorder

✍ Scribed by Piccardi, M. Paola; Severino, Giovanni; Bocchetta, Alberto; Palmas, M. Antonietta; Ruiu, Stefania; Del Zompo, Maria

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 141 KB
Volume: 74
Category: Article
ISSN: 0148-7299
DOI: 10.1002/(sici)1096-8628(19970418)74:2<137::aid-ajmg4>3.0.co;2-r

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✦ Synopsis

A recent study reported a possible association between allele 1 of the dopamine D 3 receptor gene and bipolar affective disorder using the haplotype relative risk approach. In attempt to replicate these findings, we used similar family-based methods, such as the Haplotype-Based Haplotype Relative Risk method and the Transmission Disequilibrium Test, in a sample of 44 bipolar probands from Sardinia with both parents available. Using the Bal I restriction enzyme site polymorphism of Lannfelt et al. (1992), no differences were found between transmitted and non-transmitted alleles and no evidence of linkage disequilibrium was observed. Am. J. Med. Genet. 74: 137-139, 1997.

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