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Genetics and pathogenesis of coeliac disease

✍ Scribed by Graham A. Heap; David A. van Heel


Book ID
116885580
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
475 KB
Volume
21
Category
Article
ISSN
1044-5323

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Segregation analysis favors a gene additive on liability with a frequency of 0.022, which is nearly recessive on the penetrance scale. Less than one-eighth of DR3 and DR7 haplotypes carry a determinant for coeliac disease. There is significant excess of DR3/7 heterozygotes among patients, indicating