Genetic epidemiology of coeliac disease
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J. L. Tiwari; H. Betuel; L. Gebuhrer; Dr. N. E. Morton; D. C. Rao
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Article
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1984
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John Wiley and Sons
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English
โ 309 KB
Segregation analysis favors a gene additive on liability with a frequency of 0.022, which is nearly recessive on the penetrance scale. Less than one-eighth of DR3 and DR7 haplotypes carry a determinant for coeliac disease. There is significant excess of DR3/7 heterozygotes among patients, indicating