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Genetically humanized mice recapitulate the entire hepatitis C virus life cycle

✍ Scribed by Mailly, Laurent; Zeisel, Mirjam B.; Baumert, Thomas F.

Book ID
121683971
Publisher
Elsevier Science
Year
2014
Tongue
English
Weight
440 KB
Volume
60
Category
Article
ISSN
0168-8278

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Hepatitis C virus (HCV) remains a major medical problem. Antiviral treatment is only partially effective and a vaccine does not exist. Development of more effective therapies has been hampered by the lack of a suitable small animal model. Although xenotransplantation of immunodeficient mice with hum