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Completion of the entire hepatitis C virus life cycle in genetically humanized mice

✍ Scribed by Dorner, Marcus; Horwitz, Joshua A.; Donovan, Bridget M.; Labitt, Rachael N.; Budell, William C.; Friling, Tamar; Vogt, Alexander; Catanese, Maria Teresa; Satoh, Takashi; Kawai, Taro; Akira, Shizuo; Law, Mansun; Rice, Charles M.; Ploss, Alexander

Book ID
120619433
Publisher
Nature Publishing Group
Year
2013
Tongue
English
Weight
628 KB
Volume
501
Category
Article
ISSN
0028-0836

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Hepatitis C virus (HCV) remains a major medical problem. Antiviral treatment is only partially effective and a vaccine does not exist. Development of more effective therapies has been hampered by the lack of a suitable small animal model. Although xenotransplantation of immunodeficient mice with hum