Statistical genetic mapping methods are powerful tools for "nding genes that contribute to complex human traits. Mapping methods combine knowledge of the biological mechanisms of inheritance and the randomness inherent in those mechanisms to locate, with increasing precision, trait genes on the huma
Genetic Mapping of Complex Traits: Promises, Problems, and Prospects
โ Scribed by Sun-Wei Guo; Kenneth Lange
- Book ID
- 115648573
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 146 KB
- Volume
- 57
- Category
- Article
- ISSN
- 0040-5809
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This chapter surveys current major approaches to mapping genes for multifactorial human diseases using either family-based or population-based samples. Complex, multifactorial diseases are generally hypothesized to be attributable to the effects of multiple genes with incomplete penetrance. Gene-gen
## Abstract Etiologic heterogeneity is a fundamental feature of complex disease etiology; genetic linkage analysis methods to map genes for complex traits that acknowledge the presence of genetic heterogeneity are likely to have greater power to identify subtle changes in complex biologic systems.