Linkage disequilibrium and the mapping of complex human traits
β Scribed by Kenneth M. Weiss; Andrew G. Clark
- Book ID
- 114173199
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 115 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0168-9525
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Extending the method for linkage analysis [Zhao et al., 1998a: Am. J. Med. Genet. 77:366-383; 1998b: Am. J. Med. Genet. 79:49-61], this article describes a method for the linkage-disequilibrium analysis, and for combining linkage and linkage-disequilibrium analyses. As highly dense markers are incre
## Abstract Linkage disequilibrium (LD) or association studies using caseβparent trios have become a common approach to locate unobserved susceptibility genes underlying complex diseases. With the availability of ever more dense marker maps, how to utilize the information carried by multiple marker