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Genetic mapping of complex traits

✍ Scribed by Jane M. Olson; John S. Witte; Robert C. Elston

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
168 KB
Volume
18
Category
Article
ISSN
0277-6715

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✦ Synopsis

Statistical genetic mapping methods are powerful tools for "nding genes that contribute to complex human traits. Mapping methods combine knowledge of the biological mechanisms of inheritance and the randomness inherent in those mechanisms to locate, with increasing precision, trait genes on the human genome. We provide an overview of the two major classes of mapping methods, genetic linkage analysis and linkage disequilibrium analysis, and related concepts of genetic inheritance.

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## Abstract The availability of affordable high throughput technology for parallel genotyping has opened the field of genetics to genome‐wide association studies (GWAS), and in the last few years hundreds of articles reporting results of GWAS for a variety of heritable traits have been published. W