Genetic linkage studies of chromosome 17 RFLPs in von Recklinghausen neurofibromatosis (NF1)
โ Scribed by Pericak-Vance, M.A.; Yamaoka, L.H.; Vance, J.M.; Small, K.; Rosenwasser, G.O.D.; Gaskell, P.C.; Hung, W.-Y.; Alberts, M.J.; Haynes, C.S.; Speer, M.C.
- Book ID
- 123302078
- Publisher
- Elsevier Science
- Year
- 1987
- Tongue
- English
- Weight
- 309 KB
- Volume
- 1
- Category
- Article
- ISSN
- 0888-7543
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The von Recklinghausen neurofibromatosis (NF1) gene has been mapped to the pericentromeric region of chromosome 17 and various DNA markers have been identified in this region. We have performed a genetic analysis using an anonymous DNA marker, HHH202 (D17S33), tightly linked to the NF1 gene in seven
The most common inherited syndrome in man predisposing t o neoplasia is neurofibromatosis-I (von Recklinghausen disease) (NFI). We investigated the hypothesis that affected individuals carry a single inactive allele at the NFI locus in the germline and that a tumor arises from a cell in a susceptibl