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Chromosome 17 markers and von Recklinghausen neurofibromatosis: A genetic linkage study in a British population

โœ Scribed by Upadhyaya, Meena; Sarfarazi, Mansoor; Huson, Susan M.; Stephens, Karen; Broadhead, Wendy; Harper, Peter S.


Book ID
122521324
Publisher
Elsevier Science
Year
1987
Tongue
English
Weight
316 KB
Volume
1
Category
Article
ISSN
0888-7543

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The most common inherited syndrome in man predisposing t o neoplasia is neurofibromatosis-I (von Recklinghausen disease) (NFI). We investigated the hypothesis that affected individuals carry a single inactive allele at the NFI locus in the germline and that a tumor arises from a cell in a susceptibl