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A genetic linkage study in 15 families of individuals with von Recklinghausen neurofibromatosis

✍ Scribed by Dunn, Betty G. ;Ferrell, Robert E. ;Riccardi, Vincent M. ;Opitz, John M. ;Reynolds, James F.


Book ID
101441597
Publisher
John Wiley and Sons
Year
1985
Tongue
English
Weight
341 KB
Volume
22
Category
Article
ISSN
0148-7299

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The most common inherited syndrome in man predisposing t o neoplasia is neurofibromatosis-I (von Recklinghausen disease) (NFI). We investigated the hypothesis that affected individuals carry a single inactive allele at the NFI locus in the germline and that a tumor arises from a cell in a susceptibl