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Genetic linkage analysis and molecular characterization of candidate β-secretases, BACE1 and BACE2

✍ Scribed by Saunders, Aleister J.; Park, Sung-Ming; Blacker, Deborah; Kim, Tae-Wan; Tanzi, Rudolph E.

Book ID: 122595927
Publisher: Elsevier Science
Year: 2000
Tongue: English
Weight: 190 KB
Volume: 21
Category: Article
ISSN: 0197-4580
DOI: 10.1016/S0197-4580(00)83167-X

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## Abstract Many studies suggest that BACE 1 is the genuine β-secretase; however, this is not undisputed. The wild-type (WT) β-site of the amyloid precursor protein (APP) present in the worldwide population is cleaved very slowly (__k__ ~cat~/__K__ ~m~: approx. 50 m ^-1^ s^-1^), while proteases act