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P1-158 Alterations in BACE1 and BACE2 expression and in the kinetics of β-secretase activity in the Alzheimer's disease temporal cortex

✍ Scribed by John Stockley; Rivka Ravid; Cora O'Neill

Book ID
117413034
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
163 KB
Volume
25
Category
Article
ISSN
0197-4580

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## Abstract β‐Amyloid cleaving enzyme‐1 (BACE1) has become a significant target for the therapy of Alzheimer's disease. After the discovery of the first non‐peptidomimetic β‐secretase inhibitors by Takeda Chemicals in 2001, several research teams focused on SAR development of these agents. The non‐