Kinetic properties of cathepsin D and BA
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Schechter, Israel; Ziv, Etty
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Article
📅
2008
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Walter de Gruyter GmbH & Co. KG
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English
⚖ 327 KB
## Abstract Many studies suggest that BACE 1 is the genuine β-secretase; however, this is not undisputed. The wild-type (WT) β-site of the amyloid precursor protein (APP) present in the worldwide population is cleaved very slowly (__k__ ~cat~/__K__ ~m~: approx. 50 m ^-1^ s^-1^), while proteases act