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Genetic analysis workshop II: Results of incorporating a linkage disequilibrium parameter

โœ Scribed by David E. Goldgar; Pamela R. Fain

Publisher
John Wiley and Sons
Year
1984
Tongue
English
Weight
192 KB
Volume
1
Category
Article
ISSN
0741-0395

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โœฆ Synopsis

The incorporation of a linkage disequilibrium parameter, A, into linkage analysis is illustrated for data from Genetic Analysis Workshop 11. Points from a joint likelihood surface are calculated and displayed on a recombination fraction-linkage disequilibrium grid using a simple modification of LIPED. The approach is shown to increase the power of linkage analysis and the power of tests for heterogeneity of linkage for the simulated examples.

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