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Genetic Analysis with Human—Mouse Somatic Cell Hybrids

✍ Scribed by NABHOLZ, M.; MIGGIANO, V.; BODMER, W.

Book ID
109668450
Publisher
Nature Publishing Group
Year
1969
Tongue
English
Weight
710 KB
Volume
223
Category
Article
ISSN
0028-0836

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The inherited deficiency of galactosylceramide pgalactosidase (E.C. 3.2.1.46: galactocerebrosidase) activity results in globoid cell leukodystrophy in humans (Krabbe disease) and in mice (twitcher mutant). To determine whether Krabbe patients' cells complement twitcher cells to produce, in hybrid co