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Genetic Analysis with Man–Mouse Somatic Cell Hybrids: Linkage between Human Lactate Dehydrogenase B and Peptidase B Genes

✍ Scribed by SANTACHIARA, A. SILVANA; NABHOLZ, M.; MIGGIANO, V.; DARLINGTON, A. J.; BODMER, W.

Book ID: 109674368
Publisher: Nature Publishing Group
Year: 1970
Tongue: English
Weight: 617 KB
Volume: 227
Category: Article
ISSN: 0028-0836
DOI: 10.1038/227248a0

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Chincsc hamster ovary cells with a deficiency i n Serine Hydroxymethylase which produces a specific glycine auxotrophy (gly-A) were fused with human cells from a variety of sources and the resulting hybrids analyzed for human gene linkage. Of 102 hybrid clones examined 65 possessed both glyA and lac