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Genetic analysis of the complement and coagulation pathways in atypical Hemolytic Uremic Syndrome

✍ Scribed by Smith, R.; Bu, F.; Mega, T.; Meyer, N.; Wang, K.; Thomas, C.; Nester, C.


Book ID
120661004
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
66 KB
Volume
56
Category
Article
ISSN
0161-5890

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Atypical hemolytic uremic syndrome (aHUS) is characterized by acute renal failure, thrombocytopenia and microangiopathic hemolytic anemia, and occurs with an estimated incidence in the USA of 2 per 1,000,000. Disease pathogenesis is related to dysregulation of the alternative pathway (AP) of the com