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Mutations in Proteins of the Alternative Pathway of Complement and the Pathogenesis of Atypical Hemolytic Uremic Syndrome

✍ Scribed by Cynthia Abarrategui-Garrido; Marta Melgosa; Antonia Peña-Carrión; Elena Goicoechea de Jorge; Santiago Rodríguez de Córdoba; Margarita López-Trascasa; Pilar Sánchez-Corral

Book ID
114468320
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
544 KB
Volume
52
Category
Article
ISSN
0272-6386

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Mutations in alternative pathway complem
Mutations in alternative pathway complement proteins in American patients with atypical hemolytic uremic syndrome
✍ Tara K. Maga; Carla J. Nishimura; Amy E. Weaver; Kathy L. Frees; Richard J.H. Sm 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 199 KB

Atypical hemolytic uremic syndrome (aHUS) is characterized by acute renal failure, thrombocytopenia and microangiopathic hemolytic anemia, and occurs with an estimated incidence in the USA of 2 per 1,000,000. Disease pathogenesis is related to dysregulation of the alternative pathway (AP) of the com