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Atypical hemolytic uremic syndrome in children: complement mutations and clinical characteristics

✍ Scribed by Geerdink, Lianne M.; Westra, Dineke; Wijk, Joanna A. E.; Dorresteijn, Eiske M.; Lilien, Marc R.; Davin, Jean-Claude; Kömhoff, Martin; Hoeck, Koen; Vlugt, Amerins; Heuvel, Lambertus P.; Kar, Nicole C. A. J.


Book ID
113045664
Publisher
Springer
Year
2012
Tongue
English
Weight
180 KB
Volume
27
Category
Article
ISSN
0931-041X

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Mutations in alternative pathway complem
✍ Tara K. Maga; Carla J. Nishimura; Amy E. Weaver; Kathy L. Frees; Richard J.H. Sm 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 199 KB

Atypical hemolytic uremic syndrome (aHUS) is characterized by acute renal failure, thrombocytopenia and microangiopathic hemolytic anemia, and occurs with an estimated incidence in the USA of 2 per 1,000,000. Disease pathogenesis is related to dysregulation of the alternative pathway (AP) of the com