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Complement and the atypical hemolytic uremic syndrome in children

✍ Scribed by Chantal Loirat; Marina Noris; Véronique Fremeaux-Bacchi


Publisher
Springer
Year
2008
Tongue
English
Weight
339 KB
Volume
23
Category
Article
ISSN
0931-041X

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Atypical hemolytic uremic syndrome (aHUS) is characterized by acute renal failure, thrombocytopenia and microangiopathic hemolytic anemia, and occurs with an estimated incidence in the USA of 2 per 1,000,000. Disease pathogenesis is related to dysregulation of the alternative pathway (AP) of the com