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Prevention of large-vessel stenoses in atypical hemolytic uremic syndrome associated with complement dysregulation

✍ Scribed by Jean-Claude Davin; Charles Majoie; Jaap Groothoff; Valentina Gracchi; Antonia Bouts; Timothy H. J. Goodship; Chantal Loirat


Publisher
Springer
Year
2010
Tongue
English
Weight
203 KB
Volume
26
Category
Article
ISSN
0931-041X

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De novo gene conversion in the RCA gene
✍ Stefan Heinen; Pilar Sanchez-Corral; Michael S Jackson; Lisa Strain; Judith A. G πŸ“‚ Article πŸ“… 2006 πŸ› John Wiley and Sons 🌐 English βš– 315 KB

Many of the complement regulatory genes within the RCA cluster (1q32) have arisen through genomic duplication and the resulting high degree of sequence identity is likely to predispose to gene conversion events. The highest degree of identity is between the genes for factor H (CFH) and five factor H