## Abstract Mutations in parkin are the second most common known cause of Parkinson's disease (PD). Parkin is an ubiquitin E3 ligase that monoubiquitinates and polyubiquitinates proteins to regulate a variety of cellular processes. Loss of parkin's E3 ligase activity is thought to play a pathogenic
Genes in familial parkinsonism and their role in sporadic Parkinson’s disease
✍ Scribed by Rejko Krüger
- Book ID
- 106092695
- Publisher
- Springer
- Year
- 2004
- Tongue
- English
- Weight
- 248 KB
- Volume
- 251
- Category
- Article
- ISSN
- 0340-5354
No coin nor oath required. For personal study only.
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## Abstract Recent whole genome association studies provided little evidence that polymorphisms at the familial Parkinsonism loci influence the risk for Parkinson's disease (PD). However, these studies are not designed to detect the types of subtle effects that common variants may impose. Here, we
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