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Generation of Nitrile Oxides from Oximes Using t-BuOI and Their Cycloaddition

✍ Scribed by Minakata, Satoshi; Okumura, Sota; Nagamachi, Toshiki; Takeda, Youhei


Book ID
111691651
Publisher
American Chemical Society
Year
2011
Tongue
English
Weight
974 KB
Volume
13
Category
Article
ISSN
1523-7060

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Aldoximes and ketoximes were readily synthesized from aldehydes and hydroxylamine hydrochloride on Al 2 O 3 without solvent under microwave irradiation. At higher irradiation power, aldoximes dehydrated to nitriles and ketoximes rearranged to amides. Aldoximes reacted in a one-pot reaction with Nchl

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Synthesis of Oximes, Conversion to Nitrile Oxides and Their Subsequent 1,3-Dipolar Cycloaddition Reactions under Microwave Irradiation and Solvent-Free Reaction Conditions. -Aldoximes and ketoximes (II) are readily synthesized from aldehydes and ketones (I) on Al 2 O 3 under microwave irradiation.